The 2017 AIM Annual Survey explored the 64 state, local, and territorial immunization program (IP) policies, infrastructure, program activities, and priorities related to Immunization Information Systems (IIS). The survey was administered to the immunization programs, of which 55 (86%) responded. These findings represent the view of how immunization programs support IIS’s increasing complexity and growing financial demands and what actions immunization programs take to sustain IIS in the future.